I like that the film doesn't pull punches and I like that there are consequences for the actions of the scientists. The film addresses many scientific issues, but does so with a moral and emotional center. The actress that played Dren was also strong and had the perfect mix of human, alien, and innocence. I saw it for Sarah Polley as she is one of my favorite actors and one of the most underrated ones out there today. The performances of Adrien Brody and Sarah Polley were exemplary, as always. I think it took a familiar premise and retooled it. I actually thought the film was effing brilliant. Well of COURSE they made idiotic decisions! Where's the film if they made perfectly sane decisions? What kind of film is that? Elsa stands up and is revealed to be pregnant with Dren's baby.Three fourths of these reviews hate the movie and whine about the idiot decisions of the scientists. The head of the company then thanks Elsa for the personal risk that she is undergoing. Later on, Elsa is seen in the office of the pharmaceutical company's head and is given a massive amount of money in exchange for her silence and taking the experiment to the "next stage". Dren kills Clive with a toxic sting, but is dealt a fatal blow by Elsa when she smashes its head with a rock. As Dren is raping Elsa, Clive comes to the rescue, impaling Dren with a large sharp branch. Elsa pulls him out, but he is unconscious and Elsa flees. After killing her boss and Clive's brother, Dren drags Clive into a freezing pond. Suddenly, they are attacked by Dren, who was not dead, but apparently in some sort of coma as her body underwent changes that turned her into a male. Elsa tells her boss he can dig up Dren's body if he really wants to see it. They bury Dren near the farmhouse but before they leave, their boss from pharmaceutical company arrives, having figured out that there was some sort of human hybrid because of the DNA present in the protein they had finally synthesized. Deciding to deal with Dren, they go back to the farm, only to discover her body in the water tank, apparently dead. Elsa and Clive have a heated argument about Clive having cheated, during which he confronts her with his discovery that she used samples of her own DNA in the creation of Dren. Soon after, Clive is seduced by Dren and has sex with her, much to Elsa's disgust during her sexual encounter with Clive, Dren reveals that she has regenerated her stinger. She cuts off Dren's stinger and uses organic tissue from it to finally isolate and synthesize a protein they had been searching for. Elsa, who had formed a maternal bond with Dren, changes her mind after Dren shows violent behavior, killing her own pet cat out of spite and assaulting her. Meanwhile, Dren has become amphibious and omnivorous with a toxic sting and retractable wings coming out of parts of her arm and back. Their work at the company suffers as their attention is focused on Dren. Following this meeting, N.E.R.D., found itself in danger of going out of business unless they could find a profitable discovery. This led to a disastrous presentation during a company shareholders' meeting, when the two original hybrids, previously one male and one female very much in love with each other, became both male, saw each other as rivals and bloodily killed each other in front of a shocked audience of shareholders and potential investors. One of the original hybrid animals that they had created, which was originally female, had changed sex, unbeknownst to the preoccupied Clive & Elsa. As their lab becomes exceedingly crowded, and the risk of Dren being discovered increases, they move Dren to Elsa's late mother's farm. They name their creature Dren (nerd backwards), who exceeds their wildest dreams she begins to grow and learn at an accelerated rate. Though they disagree about actually bringing the hybrid to term, Elsa pushes the issue and she persuades Clive to go along with it, in continued secrecy. Not wishing to spend all their time engaged in what they consider mundane research for the next 5-10 years, Clive and Elsa secretly conduct their own experiments, blending human DNA with that of other animals. (Nucleic Exchange Research & Development), forbids it, instead mandating that their department be reorganized to focus on finding & extracting certain proteins from the creatures they have already created. But the pharmaceutical company that funds their research, N.E.R.D. Now they want to use human DNA in a hybrid that could revolutionize science and medicine. Genetic engineers Clive Nicoli (Adrien Brody) and Elsa Kast (Sarah Polley) achieve fame by successfully splicing together the DNA of different animals to create incredible new hybrid animals.
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